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FLASH GENE
Symbol KIF21A contributors: mct/npt - updated : 13-12-2017
HGNC name kinesin family member 21A
HGNC id 19349
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal motor domain interacting with the microtubule track
  • a central coiled-coil stalk, which is a flexible connector between motor and tail that also could participate in interactions with other molecules (Shen 2008, and the third and fourth coiled-coil domains interacted with KANK1, which regulates actin polymerization, cell migration and neurite outgrowth (Kakinuma 2009)
  • kinesin-motor domain
  • a domain of seven WD-40 repeats, which may be involved in binding to cargoes (Marszalek 1999)
  • C-terminal tail with seven WD-40 repeats, that may interact with structure in the C-terminal region of ARFGEF1 (Shen 2008)
    • HOMOLOGY
    interspecies ortholog to murine Kif21a
    homolog to Drosophila klp31e
    Homologene
    FAMILY
  • Kif4-class superfamily of kinesin motors
    • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • having ATP binding activity and motor activity
  • involved in the microtubule-dependent transport of cargo in neurons
  • plus-end-directed motor protein that moves cargo on microtubules away from the microtubule-organizing center (Shen 2008)
  • N-kinesin that acts as a plus-end-directed motor to move cargo away from the microtubule-organizing center (Shen 2008)
  • slightly enhanced the translocation of KANK1 to the membrane fraction (Kakinumi 2009)
  • acts as a plus-end kinesin motor and may be involved in microtubule-dependent transport (Kakinumi 2009)
  • may be involved in the formation of vesicles at the Golgi (Kakinumi 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATp binding
    • protein
  • interacting with ARFGEF1 (Shen 2008)
  • interacting with KANK1
  • KANK1 could recruit kinesin family member 21A (KIF21A) to the cell cortex to control microtubule growth via its C-terminal ankyrin domain
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FEOM1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in congenital fibrosis of the extraocular muscles phenotypes 3(FEOM3), rare cause
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS