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FLASH GENE

Symbol

KIF21A

contributors: mct/npt - updated : 13-12-2017

HGNC name	kinesin family member 21A
HGNC id	19349

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive mouth tongue     highly Endocrine adrenal gland       highly Lymphoid/Immune spleen         Nervous brain       highly   nerve       highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal motor domain interacting with the microtubule track
	a central coiled-coil stalk, which is a flexible connector between motor and tail that also could participate in interactions with other molecules (Shen 2008, and the third and fourth coiled-coil domains interacted with KANK1, which regulates actin polymerization, cell migration and neurite outgrowth (Kakinuma 2009)
	kinesin-motor domain
	a domain of seven WD-40 repeats, which may be involved in binding to cargoes (Marszalek 1999)
	C-terminal tail with seven WD-40 repeats, that may interact with structure in the C-terminal region of ARFGEF1 (Shen 2008)

HOMOLOGY

interspecies	ortholog to murine Kif21a
	homolog to Drosophila klp31e

Homologene

FAMILY

Kif4-class superfamily of kinesin motors

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule

basic FUNCTION	having ATP binding activity and motor activity
	involved in the microtubule-dependent transport of cargo in neurons
	plus-end-directed motor protein that moves cargo on microtubules away from the microtubule-organizing center (Shen 2008)
	N-kinesin that acts as a plus-end-directed motor to move cargo away from the microtubule-organizing center (Shen 2008)
	slightly enhanced the translocation of KANK1 to the membrane fraction (Kakinumi 2009)
	acts as a plus-end kinesin motor and may be involved in microtubule-dependent transport (Kakinumi 2009)
	may be involved in the formation of vesicles at the Golgi (Kakinumi 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATp binding

protein	interacting with ARFGEF1 (Shen 2008)
	interacting with KANK1
	KANK1 could recruit kinesin family member 21A (KIF21A) to the cell cortex to control microtubule growth via its C-terminal ankyrin domain

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

FEOM1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       in congenital fibrosis of the extraocular muscles phenotypes 3(FEOM3), rare cause

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS