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FLASH GENE
Symbol KIF21A contributors: mct/npt - updated : 19-12-2009
HGNC name kinesin family member 21A
HGNC id 19349
Corresponding disease
FEOM1 congenital fibrosis of the extraocular muscles, 1
Location 12q12      Physical location : 39.687.030 - 39.837.192
Synonym name
  • NY-REN-62 antigen
  • KIF21A variant protein
  • renal carcinoma antigen NY-REN-62
  • Synonym symbol(s) FLJ20052, KIAA1708, FEOM, CFEOM, DKFZp779C159
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 149.89 kb     37 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SYT10 12 synaptotagmin X LOC390301 12 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein ALG10 12p11.21 asparagine-linked glycosylation 10 homolog (yeast, alpha-1,2-glucosyltransferase) LOC144631 12p11.21 hypothetical LOC144631 LOC260338 12p11.21 HSA12cenq11 beta-tubulin 4Q (TUBB4Q) pseudogene LOC390303 12 similar to double homeobox, 4; double homeobox protein 4 LOC390304 12 similar to KIAA0664 protein LOC121014 12p11 HSA12cenp11 beta-tubulin 4Q (TUBB4Q) pseudogene LOC390305 12 hypothetical gene supported by BX537850; NM_000267 LOC144245 12q12 similar to alpha2-glucosyltransferase CPNE8 12q12 copine VIII LOC121216 12q12 similar to Sucrase-isomaltase, intestinal KIF21A 12q12 kinesin family member 21A LOC390306 12 similar to Rpl7a protein ABCD2 12q11-q12 ATP-binding cassette, sub-family D (ALD), member 2 FLJ40126 12q12 hypothetical protein FLJ40126 SLC2A13 12p11.23 solute carrier family 2 (facilitated glucose transporter), member 13 DKFZp434H2111 12q12 hypothetical protein DKFZp434H2111 LOC390307 12 similar to submaxillary apomucin MUC19 12q12 mucin 19 CNTN1 12q11.2-q12 contactin 1 DKFZp434B0417 12q12 similar to semaF cytoplasmic domain associated protein 3 LOC283464 12q12 hypothetical protein LOC283464 YAF2 12p11.23 YY1 associated factor 2 LOC283465 12q12 similar to hepatocellular carcinoma autoantigen MADP-1 12q12 MADP-1 protein PPHLN1 12q12 periphilin 1 PRICKLE1 12q12 prickle-like 1 (Drosophila) LOC390308 12 hypothetical gene supported by NM_018464 MRPS36P5 12q12 mitochondrial ribosomal protein S36 pseudogene ADAMTS20 12q12 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 20 LOC387852 12 similar to 52 kDa repressor of the inhibitor of the protein kinase (p58IPK-interacting protein) (58 kDa interferon-induced protein kinase-interacting protein) (P52rIPK) (Death associated protein 4) (THAP domain protein 0) LOC390309 12 similar to elongation factor 1 alpha DKFZP434G1415 12q12 hypothetical protein DKFZp434G1415 IRAK4 12q12 interleukin-1 receptor-associated kinase 4 PTK9 12q12 PTK9 protein tyrosine kinase 9 DKFZp434K2435 12q12 hypothetical protein DKFZp434K2435
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    37 - 6335 - 1661 - Kakinuma (2009)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivemouthtongue  highly
    Endocrineadrenal gland   highly
    Lymphoid/Immunespleen    
    Nervousbrain   highly
     nerve   highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal motor domain interacting with the microtubule track
  • a central coiled-coil stalk, which is a flexible connector between motor and tail that also could participate in interactions with other molecules (Shen 2008, and the third and fourth coiled-coil domains interacted with KANK1, which regulates actin polymerization, cell migration and neurite outgrowth (Kakinuma 2009)
  • kinesin-motor domain
  • a domain of seven WD-40 repeats, which may be involved in binding to cargoes (Marszalek 1999)
  • C-terminal tail with seven WD-40 repeats, that may interact with structure in the C-terminal region of ARFGEF1 (Shen 2008)
  • HOMOLOGY
    interspecies ortholog to murine Kif21a
    homolog to Drosophila klp31e
    Homologene
    FAMILY
  • Kif4-class superfamily of kinesin motors
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • having ATP binding activity and motor activity
  • involved in the microtubule-dependent transport of cargo in neurons
  • plus-end-directed motor protein that moves cargo on microtubules away from the microtubule-organizing center (Shen 2008)
  • N-kinesin that acts as a plus-end-directed motor to move cargo away from the microtubule-organizing center (Shen 2008)
  • slightly enhanced the translocation of KANK1 to the membrane fraction (Kakinumi 2009)
  • acts as a plus-end kinesin motor and may be involved in microtubule-dependent transport (Kakinumi 2009)
  • may be involved in the formation of vesicles at the Golgi (Kakinumi 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATp binding
  • protein
  • interacting with ARFGEF1 (Shen 2008)
  • interacting with KANK1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FEOM1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in congenital fibrosis of the extraocular muscles phenotypes 3(FEOM3), rare cause
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS