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FLASH GENE

Symbol

SUCLA2

contributors: mct - updated : 03-11-2015

HGNC name	succinate-CoA ligase, ADP-forming, beta subunit
HGNC id	11448

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

succinate/malate coA ligase beta subunit family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix

basic FUNCTION	catalyzing the formation of succinate and ATP from succinyl-CoA and ADP in the tricarboxylic acid (TCA) cycle in a reversible manner
	subunit of succinyl-coenzyme A synthase, the enzyme that reversibly synthesises succinyl-coenzyme A and ATP from succinate, coenzyme A and ADP in the Krebs cycle

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	bind to nucleoside diphosphate kinase, both in prokaryotes and in eukaryotes
	unique interaction of SUCLA2 with ALAS2 is involved in an important erythroid-specific function

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MDDS4

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       associated to mitochondrial DNA (mtDNA) depletion syndrome (MTENC5)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS