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FLASH GENE

Symbol

PLK2

contributors: mct/shn - updated : 09-04-2013

HGNC name	polo-like kinase 2
HGNC id	19699

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol   brain basal nuclei putamen   highly Digestive mouth       highly Endocrine pancreas         Hearing/Equilibrium ear       highly Lymphoid/Immune spleen       highly Reproductive male system prostate         male system testis

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	pancreas, spleen, lung, kidney

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two polo box domains, a conserved Polo-box domain, shown to bind to phosphorylated Ser-pSer/pThr-Pro motifs

HOMOLOGY

interspecies	ortholog to Plk2, Rattus nrvegicus
	ortholog to Plk2, Mus musculus
	ortholog to PLK2, Pan trogldytes

Homologene

FAMILY

polo family of serine/threonine kinases

CATEGORY

receptor membrane serine/threonine kinase

SUBCELLULAR LOCALIZATION

basic FUNCTION	may be playing a role in the division of at least some cell types, such as fibroblasts, and could function in embryogenesis
	playing a role in the cell cycle
	mediator of activity-dependent change in the molecular composition and morphology of synapses
	is a principle contributor to alpha-synuclein phosphorylation at Ser-129 in neurons
	PLK2 phosphorylates the S589 and S595 residues of CENPJ in and this phosphorylation is critical for procentriole formation during the centrosome cycle
	NSF-Plk2 connection comprises a homeostatic sensor to directly link synaptic overactivity and subsequent downregulation in synaptic strength

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	CIB1
	with CSNK2A1 are the major kinases responsible for phosphorylation of CLIP1 at S195 and S1318, respectively
	N-ethylmaleimide-sensitive fusion protein, NSF
	SNCA is a substrate of PLK2, and elevated levels of SNCA prevent PLK2 from maintaining a normal level of GTP-bound RHO1, which is an essential GTPase that regulates stress signaling
	ROCK2, PLK2 and PLK4 are all essential for centrosomes to re-duplicate in the cells arrested by exposure to DNA synthesis inhibitor

cell & other

REGULATION

induced by

synaptic activity in hippocampal neurons

inhibited by

capacity to induce morphological changes was inhibited by the calcium- and integrin-binding protein CIB1

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS