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FLASH GENE

Symbol

PKMYT1

contributors: mct - updated : 29-09-2010

HGNC name	protein kinase, membrane associated tyrosine/threonine 1
HGNC id	29650

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004203 9 - 2121 NP_004194 55 499 - PMID: 10504341 NM_182687 9 - 2159 NP_872629 55 499 - PMID: 10504341

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus       highly Reproductive female system uterus cervix   highly   male system testis     highly

cell lineage

cell lines

fluid/secretion

at STAGE

cell cycle

cell cycle, interphase, M

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a tyrosine-serine
	threonine dual specificity tyrosine kinase catalytic domain
	C-terminal domain required for recruitment of CDK1, and this domain potentially lies in the cytoplasm because it can interact with and is phosphorylated by CDC

HOMOLOGY

interspecies

ortholog to Myt1Xe Xenopus laevis

Homologene

FAMILY	protein kinase superfamily
	Ser/Thr protein kinase family
	WEE1 subfamily

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus,nucleoplasm
text	membrane associated

basic FUNCTION	inhibitory kinase, negative regulator of the G2/M transition
	its catalytic activity was not essential for the cell cycle delay observed with human cells
	can negatively regulate CDK1/CCNB1 and inhibit G(2)/M progression by two means, both of which require the C-terminal domain (first, can bind and sequester CDK1/CCNB1 in the cytoplasm preventing entry into the nucleus, and, second, it can phosphorylate associated CDK1/CCNB1 at Thr14 and Tyr15 thus inhibiting its catalytic activity)
	dual-specificity kinase that contributes to the regulation of the cell cycle by adding inhibitory phosphates to the cyclin-dependent kinases (Cdk/cyclins)
	may be playing a key role in the G2 arrest of oocytes
	inhibitory kinase for CDK1, the master engine of mitosis, and has been thought to function, together with WEE1, as a negative regulator of mitotic entry
	essential role for Golgi and ER assembly during mitotic exit

CELLULAR PROCESS	cell cycle

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	phosphorylating and inhibiting CDC2
	interacting with STEAP3
	mediates MAP2K1 effects on the Golgi complex

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   with Wee1 induced the phosphorylation of CDC2 leading to G2/M arrest

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS