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FLASH GENE
Symbol PKMYT1 contributors: mct - updated : 29-09-2010
HGNC name protein kinase, membrane associated tyrosine/threonine 1
HGNC id 29650
DNA
TYPE functioning gene
STRUCTURE 7.68 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2121 55 499 - PMID: 10504341
9 - 2159 55 499 - PMID: 10504341
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Reproductivefemale systemuteruscervix highly
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, interphase, M
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a tyrosine-serine
  • threonine dual specificity tyrosine kinase catalytic domain
  • C-terminal domain required for recruitment of CDK1, and this domain potentially lies in the cytoplasm because it can interact with and is phosphorylated by CDC
    • HOMOLOGY
    interspecies ortholog to Myt1Xe Xenopus laevis
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • WEE1 subfamily
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm
    text membrane associated
    basic FUNCTION
  • inhibitory kinase, negative regulator of the G2/M transition
  • its catalytic activity was not essential for the cell cycle delay observed with human cells
  • can negatively regulate CDK1/CCNB1 and inhibit G(2)/M progression by two means, both of which require the C-terminal domain (first, can bind and sequester CDK1/CCNB1 in the cytoplasm preventing entry into the nucleus, and, second, it can phosphorylate associated CDK1/CCNB1 at Thr14 and Tyr15 thus inhibiting its catalytic activity)
  • dual-specificity kinase that contributes to the regulation of the cell cycle by adding inhibitory phosphates to the cyclin-dependent kinases (Cdk/cyclins)
  • may be playing a key role in the G2 arrest of oocytes
  • inhibitory kinase for CDK1, the master engine of mitosis, and has been thought to function, together with WEE1, as a negative regulator of mitotic entry
  • essential role for Golgi and ER assembly during mitotic exit
    • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • phosphorylating and inhibiting CDC2
  • interacting with STEAP3
  • mediates MAP2K1 effects on the Golgi complex
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    with Wee1 induced the phosphorylation of CDC2 leading to G2/M arrest
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS