| basic FUNCTION
| may be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities |
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specific calcium dependent signal transduction |
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potent monocyte chemoattractant involved in the regulation of neutrophils activation |
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playing a role in the pathogenesis of inflammatory bowel disease |
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may have a chaperone/antichaperone-like function which is Ca2+-dependent |
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may be involved in the pathophysiology of acute vasculitis (Kawasaki disease) |
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potential role for pro-inflammatory S100A9 and S100A12 in pathogenesis caused by inflammation and protein complex formation in Alzheimer disease (AD)  |
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is an important factor in host/parasite defenses and in the inflammatory response |
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role of S100A12 in the cross talk between zinc and calcium in cell signaling |
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S100A12 expression is sufficient to activate pathogenic pathways through the modulation of oxidative stress, inflammation and vascular remodeling |
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besides RAGE scavenger receptors contribute to distribution, tissue association and elimination of circulating proinflammatory S100A12 |
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vascular smooth muscle S100A12 accelerates atherosclerosis and augments atherosclerosis-triggered osteogenesis, reminiscent of features associated with plaque instability |
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possible involvement of S100A12 in the development of osteoarthritis (OA) by up-regulating MMP13 and VEGFA via MAPK14 and NFKB1 pathways |
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RETN, S100A12 and AGER are involved in the pathophysiology of Kawasaki disease (KD) |
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is a pro-inflammatory protein expressed in neutrophils whose structure and function are modulated by both Ca(2+) and Zn(2+) |
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might participate in the damage of biliary epithelial cells and hepatocytes in primary biliary cirrhosis (PBC)5) |
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S100A8/A9 (calprotectin) and S100A12 proinflammatory mediators are found at inflammatory sites and in the serum of patients with inflammatory or autoimmune diseases |
