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FLASH GENE

Symbol

POLR1D

contributors: npt/mct - updated : 05-07-2017

HGNC name	polymerase (RNA) 1 polypeptide D, 16kDa
HGNC id	20422

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	45.55 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015972 2 - 725 NP_057056 - 133 - Hu (2002) NM_152705 3 - 1977 NP_689918 - 122 - Hu (2002)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

PhosphoP

HOMOLOGY

interspecies

ortholog to yeasrAC40

Homologene

FAMILY

archaeal rpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus

basic FUNCTION	biosynthesis ot rRNA
	may play a role for the kidney aging (Wheeler 2009)

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

purine/pyrimidine

signaling

a component	component of the multisubunit complex of eukaryotic nuclear RNA polymerase producing ribosomal RNA
	binding to ribosomal genes in association with the C subunit

INTERACTION

DNA

binding

RNA

small molecule

protein

interacting with MAF1 (MAF1 is a major regulator of pol III and POLR1D transcription in human cells) (Reina 2006)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

TCSPD

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS