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FLASH GENE

Symbol

POLR1B

contributors: KTN/npt - updated : 07-01-2008

HGNC name	polymerase (RNA) I polypeptide B, 128kDa
HGNC id	20454

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q13      Physical location : 113.299.491 - 113.334.727
Synonym name	DNA-directed RNA polymerase I subunit RPA2
	RNA polymerase I subunit 2
Synonym symbol(s)	RPA135, RPO1-2, FLJ10816, FLJ21921, MGC131780
EC.number	2.7.7.6

DNA

TYPE	functioning gene
STRUCTURE	35.00 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 15 - 5968 128 1135 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     predominantly Respiratory respiratory tract trachea     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     moderately Muscular       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a C4 type zinc finger

HOMOLOGY

interspecies	homolog to chimpanzee POLR1B (99.6 pc)
	homolog to rattus Rpo1-2 (90.8 pc)
	homolog to murine Rpo1-2 (89.7 pc)

Homologene

FAMILY

RNA polymerase beta chain family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus

basic FUNCTION	catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
	proposed to contribute to the polymerase catalytic activity and forming the polymerase active center together with the largest subunit

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

purine/pyrimidine

signaling

biosynthesis of rRNA

a component	component of the multisubunit complex of eukaryotic nuclear DNA directed RNA polymerase producing ribosomal RNA, brought to ribosomal genes as a distinct subunit
	second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS