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FLASH GENE
Symbol ICAM3 contributors: mct - updated : 20-04-2013
HGNC name intercellular adhesion molecule 3
HGNC id 5346
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • a signal sequence,
  • an extracellular region with five Ig-like domains
  • a single transmembrane segment (1TM)
  • a cytoplasmic C terminus, containing a positively charged aminoacid cluster in the juxtamembrane cytoplasmic domain, ERM proteins binding
    • HOMOLOGY
    Homologene
    FAMILY Ig superfamily, ICAM subfamily
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION functioning not only as an adhesion molecule, but also as a potent signalling molecule
    CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for LFA1, counterreceptor
  • interacting with moesin and promoting its redistribution to the uropod of T-lymphocytes during cell polarization
  • interacting with CD209 (Geijtenbeek 2000)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS