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FLASH GENE

Symbol

ICAM3

contributors: mct - updated : 20-04-2013

HGNC name	intercellular adhesion molecule 3
HGNC id	5346

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly   thymus       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol   bone marrow       Homo sapiens Adult

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Blood/Hematopoietic mature hematopoietic Homo sapiens Adult

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		basic
STRUCTURE

motifs/domains	a signal sequence,
	an extracellular region with five Ig-like domains
	a single transmembrane segment (1TM)
	a cytoplasmic C terminus, containing a positively charged aminoacid cluster in the juxtamembrane cytoplasmic domain, ERM proteins binding

HOMOLOGY

Homologene

FAMILY

Ig superfamily, ICAM subfamily

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I transmembrane protein

basic FUNCTION

functioning not only as an adhesion molecule, but also as a potent signalling molecule

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	ligand for LFA1, counterreceptor
	interacting with moesin and promoting its redistribution to the uropod of T-lymphocytes during cell polarization
	interacting with CD209 (Geijtenbeek 2000)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS