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FLASH GENE

Symbol

DPP10

contributors: mlc - updated : 24-11-2007

HGNC name	dipeptidylpeptidase 10
HGNC id	20823

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 2 or DPL2-s - - 4464 - 789 highly in the brain Ren, Chen (2006) contains a distinct 5' UTR and has an alternative exon at the 5' end of the coding region has a shorter and distinct N-terminus when compared to the long isoform lacking dipeptidyl peptidase activity variant 1 or DPL2-l 26 - 4863 90.9 796 - Ren, Chen (2006) the longer transcript and encodes the 'long' isoform

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon amygdala     nervous brain basal nuclei       Nervous brain diencephalon thalamus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine Dpp10
	ortholog to ratus Dpp10_predicted

intraspecies

homolog to DPP6

Homologene

FAMILY	peptidase family S9B
	dipeptidyl peptidase IV (DPIV) gene family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION

cleaving terminal dipeptides from cytokines and chemokines, and presents a potential new target for asthma therapy

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binds KCND2, KCND1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         asthma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS