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FLASH GENE

Symbol

GBP2

contributors: mct - updated : 01-10-2014

HGNC name	guanylate binding protein 2, interferon-inducible
HGNC id	4183

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	20.03 kb     11 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004120 11 - 4148 NP_004111 67.1 591 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus         Cardiovascular heart         Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal globular GTPase
	C-terminal CaaX-prenylation signal, which is typical for small GTPases of the Ras family, and increases the membrane affinity of proteins , alpha-helical regulatory domain that are connected by a short middle domain

HOMOLOGY

Homologene

FAMILY

guanylate binding protein (GBP) family

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus
text	prenylated and prenylation is required for the membrane association
	GBP1, GBP3, and GBP5 were exclusively detected in the cytoplasm, whereas GBP2 and GBP4 displayed a nucleocytoplasmic distribution

basic FUNCTION	involved in immune response
	GBP1, GBP2 and GBP5 were able to redirect non-prenylated GBPs to their compartment in a prenylation-dependent manner
	is potentially an essential immune effector molecule mediating antiparasitic resistance

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

TP53 up-regulates GBP2 by cooperating with IRF1

cell & other

REGULATION

induced by	interferon gamma during macrophage activation.
		IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) inducing the expression of GBP1, GBP2, and GBP3 at similar high levels

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast carcinomas was associated with better prognosis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS