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FLASH GENE
Symbol GBP2 contributors: mct - updated : 01-10-2014
HGNC name guanylate binding protein 2, interferon-inducible
HGNC id 4183
Location 1p22.2      Physical location : 89.573.309 - 89.591.799
Synonym name GTP-binding protein 2
Synonym symbol(s) HuGBP-2
DNA
TYPE functioning gene
STRUCTURE 20.03 kb     11 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 4148 67.1 591 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Cardiovascularheart    
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal globular GTPase
  • C-terminal CaaX-prenylation signal, which is typical for small GTPases of the Ras family, and increases the membrane affinity of proteins , alpha-helical regulatory domain that are connected by a short middle domain
    • HOMOLOGY
    Homologene
    FAMILY
  • guanylate binding protein (GBP) family
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text
  • prenylated and prenylation is required for the membrane association
  • GBP1, GBP3, and GBP5 were exclusively detected in the cytoplasm, whereas GBP2 and GBP4 displayed a nucleocytoplasmic distribution
    • basic FUNCTION
  • involved in immune response
  • GBP1, GBP2 and GBP5 were able to redirect non-prenylated GBPs to their compartment in a prenylation-dependent manner
  • is potentially an essential immune effector molecule mediating antiparasitic resistance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TP53 up-regulates GBP2 by cooperating with IRF1
    • cell & other
    REGULATION
    induced by interferon gamma during macrophage activation.
    IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) inducing the expression of GBP1, GBP2, and GBP3 at similar high levels
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast carcinomas was associated with better prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS