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FLASH GENE
Symbol PRMT6 contributors: mct/npt/pgu - updated : 22-08-2014
HGNC name protein arginine N-methyltransferase 6
HGNC id 18241
Location 1p13.3      Physical location : 107.599.266 - 107.601.907
Synonym name
  • HMT1 hnRNP methyltransferase-like 6 (S. cerevisiae)
  • histone-arginine N-methyltransferase PRMT6
  • heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6
  • Synonym symbol(s) FLJ10559, ANM6, HRMT1L6, FLJ51477
    EC.number 2.1.1-, 2.1.1.125
    DNA
    TYPE functioning gene
    STRUCTURE 2.65 kb     1 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391064 1 hypothetical gene supported by AK001388 LOC126987 1p13.3 similar to tight junction protein 3 (zona occludens 3) PRMT6 1p13.3 similar to tight junction protein 3 (zona occludens 3) NTNG1 1p13.3 netrin G1 LOC360165  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa, pseudogene VAV3 1p22.3-p11 vav 3 oncogene DKFZp586G0123 1p13.3 calcium-binding transporter FLJ32833 1p13.3 hypothetical protein FLJ32833 LOC388657 1 similar to calcium-binding transporter LOC343141 1p13.3 similar to calcium-binding transporter LOC388658 1 similar to hypothetical protein MGC8902 LOC388659 1 similar to RIKEN cDNA C230093N12 FLJ30525 1p13.3 hypothetical protein FLJ30525 FLJ10330 1p13.3 hypothetical protein FLJ10330 FLJ35838 1p13.3 hypothetical protein FLJ35838 STXBP3 1p21-p13.3 syntaxin binding protein 3 MGC26989 1p13.3 hypothetical protein MGC26989 LGN MCLC 1p13.2 hypothetical protein MGC26989 KIAA0893 1p13.3 hypothetical protein MGC26989 NDUFB3P1 1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 1 AD-020 1p13.3 protein x 013 LOC391065 1 similar to poly(rC) binding protein 1; heterogenous nuclear ribonucleoprotein X; poly(rC)-binding protein 1; alpha-CP1; nucleic acid binding protein sub 2.3; heterogenous nuclear ribonucleoprotein E1 LOC127003 1p13.3 similar to CG5435-PA KIAA1324 1p13.2 maba1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2665 - 375 - 2005 16157300
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarybladder    
     kidney    
    Visualeyelacrimal gland   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Respiratoryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Prmt6 (94.0pc)
    Homologene
    FAMILY
  • protein arginine N-methyltransferase family
  • PRMT6 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • predominantly in nucleus
  • basic FUNCTION
  • methylating (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain
  • acting as a restriction factor for HIV replication
  • specifically methylates the nonhistone chromatin protein HMGA1
  • plays a role as a regulator of DNA base excision repair
  • regulate DNA repair and gene expression
  • mammalian methyltransferase for H3 R2 and a crucial negative regulator of H3 K4 trimethylation and transcriptional activation
  • functioning as a transcriptional coactivator that can also regulate alternative splicing
  • has a dual role in regulating gene expression and that these two functions can occur independently of each other
  • dysregulation of PRMT1 and PRMT6 can be involved in human carcinogenesis
  • utilizes a rapid equilibrium random mechanism with dead-end EAP and EBQ complexes
  • is potentially important for ES cell pluripotency and self-renewal
  • facilitates cell proliferation and blocks senescence by regulation of tumor suppressor genes and that this might contribute to the oncogenic capacity of PRMT6
  • methylate the HMGA1 protein in the second AT hook and likely regulates chromatin structure organization
  • regulates cell cycle progression
  • implicated in transcriptional regulation, DNA repair, and human immunodeficiency virus pathogenesis
  • its overexpression is associated with regulation of motility and invasion through up-regulation of THBS1 and down-regulation of MMPs in cancer cells
  • arginine methyltransferase known to methylate AT-hook motifs, downregulating the expression of HLA-DQ, but not HLA-DR, in an AT-hook-dependent manner
  • PRMT6 is involved in the regulation of hepatic glucose metabolism in a CRTC2-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly regulates the THBS1 promoter activity (THBS1 is a transcriptional repression target of PRMT6)
  • regulates gene transcription via its ability to methylate histones H3 and H4
  • CDKN1A is a direct target of PRMT6 and the corresponding histone mark H3R2me2
  • HMGA1 is a substrate for PRMT6, having a modulatory role on the methyltransferase activity of PRMT6
  • negative function of PRMT6 on invasion and migration of cancer cells through up-regulation of THBS1 and down-regulation of MMP2 and MMP9
  • PELP1 interacts with the arginine methyltransferase PRMT6 and modifies PRMT6 functions
  • in cells, PRMT6 mediated asymmetric dimethylation of multiple arginine residues of CRTC2, which enhanced the association of CRTC2 with CREB on the promoters of gluconeogenic enzyme-encoding genes
  • cell & other
    REGULATION
    Other automethylation activity
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    associated with regulation of motility and invasion through up-regulation of THBS1 and down-regulation of MMPs in cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS