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FLASH GENE
Symbol ZNF331 contributors: mct - updated : 08-10-2014
HGNC name zinc finger protein 331
HGNC id 15489
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one KRAB domain, Krüppel-associated box at the N terminus
  • twelve tandemly arranged C2H2 Krüppel type zinc finger motifs at the C terminus
    • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to chimpanzee znf331
    ortholog to dog znf331
    Homologene
    FAMILY zinc finger protein family C2H2 type, KRAB subfamily
    CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may be playing a role in renal development
  • involved in the repair of the kidney after ischemia- reperfusion or folic acid administration
  • blocking TP53-MDM2 interactiona, activating TP53 in tumors and inducing massive apoptosis ( candidate for anticancer drugs that targets tumors with wild-type TP53)
  • involved in the development of follicular adenomas
  • possesses important functions for the suppression of gastric carcinogenesis as a novel functional tumor-suppressor gene
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein binding to TP53 and inducing its accumulation in tumor cells
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    t(5;19) (q13;q13)and t(1;19) (p35-p36.1;q13) in thyroid adenomas
    tumoral   deletion    
    in thyroid follicular adenoma
    tumoral     --low  
    in 71p100 gastric cancer cell lines, by promoter hypermethylation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS