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FLASH GENE
Symbol GPR103 contributors: mlc - updated : 16-07-2007
HGNC name G protein-coupled receptor 103
HGNC id 15565
DNA
TYPE functioning gene
STRUCTURE 51.00 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivemouth   predominantly
Endocrineadrenal gland   highly
Nervousbraindiencephalonhypothalamus  
Reproductivemale systemtestis  highly
Urinarykidney   highly
Visualeyeretina  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Skeletonosteoblast
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
conjugated GlycoP
HOMOLOGY
interspecies homolog to chimpanzee GPR103 (97.7 pc)
homolog to rattus Gpr103 (83.8 pc)
homolog to murine Gpr103 (83.3 pc)
Homologene
FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a receptor for the orexigenic neuropeptide QRFP
  • acting as a rhodopsin-like receptor
  • regulating diverse neuroendocrine and behavioral functions
  • implicating this neuropeptide system in metabolic syndrome
  • regulating bone formation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in osteopenia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS