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FLASH GENE
Symbol GCET2 contributors: mct/npt/pgu - updated : 30-05-2009
HGNC name germinal center expressed transcript 2
HGNC id 20253
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one ITAM motif (immunoreceptor tyrosine-based activation motif)
  • five conserved putative tyrosine phosphorylation sites (Pan 2007)
  • a structural domain that mediates its interaction with the PDZ-RhoGEF protein
  • C-terminal tyrosine residue
    • HOMOLOGY
    interspecies homolog to murine M17
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    text
  • expressed in the cytoplasm of germinal center lymphocytes
  • constitutively localised in the plasma membrane but is excluded from lipid rafts
    • basic FUNCTION
  • may have an important role in the diagnosis of specific lymphomas, and, potentially in the identification of subtypes associated with different prognoses
  • involved in negative regulation of lymphocyte migration, thus constraining lymphocytes to the germinal center
  • may be an adaptor protein in GC B cells that transduces signals from GC B-cell membrane to the cytosol via its association with GRB2
  • germinal center (GC)-specific gene that negatively regulates lymphocyte motility and whose expression predicts improved survival of patients with diffuse large B-cell lymphoma (DLBCL) and classical Hodgkin lymphoma (cHL)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with IL6 (IL6 induces the phosphorylation of the C-terminal tyrosine residue of GCET2 via the Lyn kinase, and promotes its relocalization from the cytoplasm to podosome-like structures)
  • associate with GRB2 through the third tyrosine following phosphorylation
    • cell & other
    REGULATION
    induced by IL4 in B cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    correlated with survival in patients with diffuse large B-cell lymphoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene useful marker for germinal centre (GC) B cells and GC B-cell derived malignancies, including follicular lymphomas and germinal centre B cell-like diffuse large B-cell lymphomas (GCB-DLBCLs), and is a useful prognosticator for DLBCLs
    Marker
    Therapy target
    ANIMAL & CELL MODELS