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FLASH GENE

Symbol

GCET2

contributors: mct/npt/pgu - updated : 30-05-2009

HGNC name	germinal center expressed transcript 2
HGNC id	20253

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 6 - 3314 21 178 - 2005 15677569 variant 2 6 - 3481 - 112 - 2005 15677569

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node           spleen           thymus

cells

System Cell Pubmed Species Stage Rna symbol lymphoid immune lymphocyte

cell lineage
cell lines
fluid/secretion	lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one ITAM motif (immunoreceptor tyrosine-based activation motif)
	five conserved putative tyrosine phosphorylation sites (Pan 2007)
	a structural domain that mediates its interaction with the PDZ-RhoGEF protein
	C-terminal tyrosine residue

HOMOLOGY

interspecies

homolog to murine M17

Homologene

FAMILY

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,nucleus
text	expressed in the cytoplasm of germinal center lymphocytes
	constitutively localised in the plasma membrane but is excluded from lipid rafts

basic FUNCTION	may have an important role in the diagnosis of specific lymphomas, and, potentially in the identification of subtypes associated with different prognoses
	involved in negative regulation of lymphocyte migration, thus constraining lymphocytes to the germinal center
	may be an adaptor protein in GC B cells that transduces signals from GC B-cell membrane to the cytosol via its association with GRB2
	germinal center (GC)-specific gene that negatively regulates lymphocyte motility and whose expression predicts improved survival of patients with diffuse large B-cell lymphoma (DLBCL) and classical Hodgkin lymphoma (cHL)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with IL6 (IL6 induces the phosphorylation of the C-terminal tyrosine residue of GCET2 via the Lyn kinase, and promotes its relocalization from the cytoplasm to podosome-like structures)
	associate with GRB2 through the third tyrosine following phosphorylation

cell & other

REGULATION

induced by

IL4 in B cells

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   correlated with survival in patients with diffuse large B-cell lymphoma

Susceptibility

Variant & Polymorphism

Candidate gene	useful marker for germinal centre (GC) B cells and GC B-cell derived malignancies, including follicular lymphomas and germinal centre B cell-like diffuse large B-cell lymphomas (GCB-DLBCLs), and is a useful prognosticator for DLBCLs
Marker
Therapy target

ANIMAL & CELL MODELS