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FLASH GENE

Symbol

COQ4

contributors: mct/npt - updated : 26-02-2015

HGNC name	coenzyme Q4 homolog (S. cerevisiae)
HGNC id	19693

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016035 7 - 1597 NP_057119 - 265 - 2012 18474229 variant 2 - - - - 241 - 2012 18474229 lacks the mitochondrial targeting sequence localized mainly to the cytosol

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary     highly Nervous brain         Reproductive female system uterus cervix   highly Respiratory respiratory tract trachea     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

fetal eye

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a predicted N-terminal mitochondrial targeting sequence

HOMOLOGY

interspecies

ortholog to yeast Coq4

Homologene

FAMILY

COQ4 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane
	intracellular,nucleus
text	associated with the mitochondrial inner membrane on the matrix side

basic FUNCTION	involved in coenzyme q biosynthesis
	may be a core component of multisubunit complex required for CoQ biosynthesis
	potentially playing a structural role crucial in the stabilization of a multiheteromeric complex including several, if not all, of the CoQ biosynthetic enzymes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

COQ10D7

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS