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FLASH GENE
Symbol APBB1IP contributors: mct - updated : 06-07-2016
HGNC name amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
HGNC id 17379
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PH domain
  • a RAS-associating domain
  • two pro-rich regions required for the suppression of AP1 transcription activity
    • HOMOLOGY
    intraspecies homolog to C. elegans MIG-10 protein
    homolog to Grb7-family of signaling adaptors
    Homologene
    FAMILY MRL (Mig-10/RIAM/Lamellipodin) protein family
    CATEGORY adaptor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • involved in neuropeptide signaling pathway
  • functioning in the signal transduction from RAS activation to actin cytoskeletal remodelling
  • suppresses insulin- induced promoter activities through AP1 and SRE
  • mediating RABGEF1- induced adhesion
  • activates integrins by linking talin to RAS GTPase membrane-targeting sequences
  • plays a critical role in actin reorganization and inside-out activation of integrins in lymphocytes and platelets
  • adaptor protein that mediates talin recruitment to the cell membrane
  • in cells, APBBIP1 is enriched in nascent adhesions at the leading edge whereas VCL is enriched in focal adhesions (FAs)
  • is a critical component of the phagocytosis machinery downstream of RABGEF1 and mediates its function by recruiting talin to the phagocytic complement receptors
  • novel role in conformational regulation of talin during integrin activation and cell adhesion
  • role for APBB1IP in the regulation of some, but not all, leukocyte integrins, suggesting that APBB1IP-regulated integrin activation is required for trafficking of lymphocytes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts, through the N-terminal pro-rich region, with the WW domain of APBB1
  • interacts with RABGEF1, PFN1, VASP and ENAH
  • first direct link between RAS signaling and cytoskeletal remodelling via VASP proteins during cell migration and spreading
  • by regulating the localization of PLCG1, plays a central role in TCR signaling and the transcription of target genes
  • integrin-triggered, APBB1IP-dependent MEK activation represents a key feedback event required for efficient focal adhesion (FA) disassembly, which could help explain the role of APBB1IP in cell migration and invasion
  • RABGEF1 regulates ITGB2 adhesiveness through one of its effectors, RABGEF1-interacting adapter molecule (APBB1IP)
  • RAP1A induces integrin activation via an inside-out signaling pathway mediated by APBB1IP
  • two effectors of RAP1A regulate integrins, RASSF5 and APBB1IP
  • role of the RABGEF1-APBB1IP, in leukocyte integrin activation and consequently in leukocyte trafficking
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS