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FLASH GENE

Symbol

APBB1IP

contributors: mct - updated : 06-07-2016

HGNC name	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
HGNC id	17379

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_019043 15 - 2659 NP_061916 - 666 - 2013 23420480

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly   spleen       highly   thymus       highly   tonsils       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Epithelial sensory olfactory

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a PH domain
	a RAS-associating domain
	two pro-rich regions required for the suppression of AP1 transcription activity

HOMOLOGY

intraspecies	homolog to C. elegans MIG-10 protein
	homolog to Grb7-family of signaling adaptors

Homologene

FAMILY

MRL (Mig-10/RIAM/Lamellipodin) protein family

CATEGORY

adaptor , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus

basic FUNCTION	involved in neuropeptide signaling pathway
	functioning in the signal transduction from RAS activation to actin cytoskeletal remodelling
	suppresses insulin- induced promoter activities through AP1 and SRE
	mediating RABGEF1- induced adhesion
	activates integrins by linking talin to RAS GTPase membrane-targeting sequences
	plays a critical role in actin reorganization and inside-out activation of integrins in lymphocytes and platelets
	adaptor protein that mediates talin recruitment to the cell membrane
	in cells, APBBIP1 is enriched in nascent adhesions at the leading edge whereas VCL is enriched in focal adhesions (FAs)
	is a critical component of the phagocytosis machinery downstream of RABGEF1 and mediates its function by recruiting talin to the phagocytic complement receptors
	novel role in conformational regulation of talin during integrin activation and cell adhesion
	role for APBB1IP in the regulation of some, but not all, leukocyte integrins, suggesting that APBB1IP-regulated integrin activation is required for trafficking of lymphocytes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts, through the N-terminal pro-rich region, with the WW domain of APBB1
	interacts with RABGEF1, PFN1, VASP and ENAH
	first direct link between RAS signaling and cytoskeletal remodelling via VASP proteins during cell migration and spreading
	by regulating the localization of PLCG1, plays a central role in TCR signaling and the transcription of target genes
	integrin-triggered, APBB1IP-dependent MEK activation represents a key feedback event required for efficient focal adhesion (FA) disassembly, which could help explain the role of APBB1IP in cell migration and invasion
	RABGEF1 regulates ITGB2 adhesiveness through one of its effectors, RABGEF1-interacting adapter molecule (APBB1IP)
	RAP1A induces integrin activation via an inside-out signaling pathway mediated by APBB1IP
	two effectors of RAP1A regulate integrins, RASSF5 and APBB1IP
	role of the RABGEF1-APBB1IP, in leukocyte integrin activation and consequently in leukocyte trafficking

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS