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FLASH GENE
Symbol ANGPTL5 contributors: mct - updated : 06-06-2016
HGNC name angiopoietin-like 5
HGNC id 19705
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal 25 aa cleavable signal peptide
  • a predicted coiled-coil domain
  • a fibrinogen-like domain
    • conjugated GlycoP
    isoforms Precursor a 363 aa mature proteine
    HOMOLOGY
    interspecies homolog to chicken angptl5
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • inducing sprouting in endothelial cells through an autocrine and paracrine action
  • ANGPTL3, ANGPTL4, and ANGPTL5, but not ANGPTL6, play nonredundant roles in triglyceride metabolism
  • ANGPTL3, ANGPTL4, and possibly ANGPTL5 are regulators of lipoprotein metabolism
  • ANGPTL4 and ANGPTL5 can lead to increased engraftment capacity of NOD/SCID-repopulating cells (SRCs)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ANGPTL5 supports expansion of human cord blood hematopoietic stem cells in a process at least partially mediated by the surface receptor LILRB2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS