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FLASH GENE
Symbol ANAPC1 contributors: mct - updated : 02-10-2019
HGNC name anaphase promoting complex subunit 1
HGNC id 19988
Corresponding disease
RTS2 Rothmund-Thomson syndrome 2
Location 2q13      Physical location : 112.526.640 - 112.641.741
Synonym name
  • anaphase-promoting complex 1 (meiotic checkpoint regulator)
  • cyclosome subunit 1
  • testis-specific gene 24 protein
    • Synonym symbol(s) APC1, MCPR, TSG24
    DNA
    TYPE functioning gene
    STRUCTURE 118.05 kb     48 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    48 - 6329 - 1944 - 2016 27939943
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four proteasome/cyclosome (PC) repeats
  • N-terminal domain of Apc1 (Apc1N) having WD40 (WD40 repeat) domain (Apc1(WD40)
    • HOMOLOGY
    interspecies homolog to murine Apc1
    Homologene
    FAMILY
  • APC1 (anaphase-promoting complex) family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • controlling progresion through anaphase by triggering the degradation of cell cycle regulators such securin and B-type cyclin
  • orchestrates progression through mitosis by decorating cell-cycle regulators with ubiquitin chains (Jin 2008)
  • plays roles in the control of senescence, quiescence, DNA replication and repair, cell differentiation, metabolism, and neuronal function
  • regulates the ubiquitin-dependent proteolysis of specific cell-cycle proteins to coordinate chromosome segregation in mitosis and entry into the G1 phase
  • is a large multimeric cullin-RING E3 ubiquitin ligase that orchestrates cell-cycle progression by targeting cell-cycle regulatory proteins for destruction via the ubiquitin proteasome system
    • CELLULAR PROCESS cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ubiquitin dependent catabolism
    a component
  • member of the anaphase promoting/cyclosome complex (APC/C) is a large E3 ubiquitin ligase containing at leastten different, evolutionarily conserved components
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RTS2
    Susceptibility
  • to alcool and nicotine dependence
    • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS