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FLASH GENE
Symbol AGTRAP contributors: SGE/npt - updated : 05-10-2009
HGNC name angiotensin II receptor-associated protein
HGNC id 13539
Location 1p36.22      Physical location : 11.796.141 - 11.810.827
Synonym name ATI receptor-associated protein
Synonym symbol(s) ATRAP, ARAP1, MGC29646
DNA
TYPE functioning gene
STRUCTURE 14.69 kb     6 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1200 - 159 - Guo
  • isoform a
  • 5 - 1179 - 152 - Guo
  • isoform b
  • 4 - 1144 - 111 - Guo
  • isoform c
  • 6 - 1276 - 155 - Guo
  • isoform d
  • 6 - 1297 - 147 - Guo
  • isoform e
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivesalivary gland   highly
    Endocrinepancreas   highly
     thyroid   highly
    Nervousnervecranial nerve  highly
    Reproductivefemale systemuteruscervix highly
    Skin/Tegumentskin   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoptic nerve
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Agtrap (75.5pc)
    homolog to murine Agtrap (77.4pc)
    Homologene
    FAMILY
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • playing a role in the recycling of the AT(1) receptor to the plasma membrane with presumable concomitant recovery of receptor signal functions
  • negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation or by receptor desensitization such as phosphorylation
  • inducing also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity
  • downregulating AT1R and attenuating certain angiotensin II-mediated hypertrophic responses in cardiomyocytes (Tanaka 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1
  • interaction with CAMLG may mediate the AGT actions in vascular physiology
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS