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FLASH GENE
Symbol SYCP1 contributors: mct - updated : 22-06-2016
HGNC name synaptonemal complex protein 1
HGNC id 11487
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal rich in acidic AAs
  • a predicted alpha-helical domain
  • a C terminal domain rich in basic AAs and herboring S/T-P and S/T-S/T involved in DNA binding
  • two potential nuclear localization signals (NLS)
  • a potential p34 cdc2 (CDC2) target site and a leucine zipper
    • HOMOLOGY
    interspecies homolog to murine Scp1
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text in tripartite segments of synaptonemal complexes, between lateral elements in the nucleus
    basic FUNCTION
  • transverse filament protein involved in the structural organization of meiotic prophase chromosomes
  • primary determinant of synaptonemal complexes assembly that plays a key role in synapsis of homologous chromosomes
  • involved with SYCP1 and SYCE2 in synaptonemal complex assembly
  • in addition to their roles as synaptonemal complex components, SYCP1 and SYCP3 act at the centromeres to promote the establishment and/or maintenance of centromere pairing and, by doing so, improve the segregation fidelity of mammalian meiotic chromosomes
  • SYCP1 and SYCE3 form a joint bilayered central structure
    • CELLULAR PROCESS cell cycle,division,meiosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of synaptonemal complex protein 1, axial element
  • SYCE1 interacts more directly with SYCP1 and could thus anchor the central element proteins to the transverse filaments
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interact with SYCE1, SYCE2, for their localisation to the central element
  • with SCYP2, interact in extracts of meiotic cells
  • interaction with FKBP6 (crucial factor in spermatogenesis because of its interplay with the synaptonemal complex protein SYCP1)
  • PLK1, phosphorylates central element proteins SYCP1 and TEX12, and PLK-mediated phosphorylation of central element proteins is required for meiotic prophase exit
  • disruption of SYCE2 and TEX12 (a fourth central element protein) localization to the central element abolishes central alignment of the N-terminal region of SYCP1
  • PUM1 facilitates the transition of the late meiotic prophase I oocyte from pachytene to diplotene stage by regulating SYCP1 protein
  • C1ORF146 interacts with synaptonemal complex protein 1 (SYCP1) and synaptonemal complex central element 3 (SYCE3)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS