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FLASH GENE

Symbol

SYCP1

contributors: mct - updated : 22-06-2016

HGNC name	synaptonemal complex protein 1
HGNC id	11487

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	140.54 kb     32 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003176 32 - 3503 NP_003167 114 976 - 2005 15944401

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     specific Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal rich in acidic AAs
	a predicted alpha-helical domain
	a C terminal domain rich in basic AAs and herboring S/T-P and S/T-S/T involved in DNA binding
	two potential nuclear localization signals (NLS)
	a potential p34 cdc2 (CDC2) target site and a leucine zipper

HOMOLOGY

interspecies

homolog to murine Scp1

Homologene

FAMILY

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	in tripartite segments of synaptonemal complexes, between lateral elements in the nucleus

basic FUNCTION	transverse filament protein involved in the structural organization of meiotic prophase chromosomes
	primary determinant of synaptonemal complexes assembly that plays a key role in synapsis of homologous chromosomes
	involved with SYCP1 and SYCE2 in synaptonemal complex assembly
	in addition to their roles as synaptonemal complex components, SYCP1 and SYCP3 act at the centromeres to promote the establishment and/or maintenance of centromere pairing and, by doing so, improve the segregation fidelity of mammalian meiotic chromosomes
	SYCP1 and SYCE3 form a joint bilayered central structure

CELLULAR PROCESS	cell cycle,division,meiosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	constituent of synaptonemal complex protein 1, axial element
	SYCE1 interacts more directly with SYCP1 and could thus anchor the central element proteins to the transverse filaments

INTERACTION

DNA

binding

RNA

small molecule

protein	interact with SYCE1, SYCE2, for their localisation to the central element
	with SCYP2, interact in extracts of meiotic cells
	interaction with FKBP6 (crucial factor in spermatogenesis because of its interplay with the synaptonemal complex protein SYCP1)
	PLK1, phosphorylates central element proteins SYCP1 and TEX12, and PLK-mediated phosphorylation of central element proteins is required for meiotic prophase exit
	disruption of SYCE2 and TEX12 (a fourth central element protein) localization to the central element abolishes central alignment of the N-terminal region of SYCP1
	PUM1 facilitates the transition of the late meiotic prophase I oocyte from pachytene to diplotene stage by regulating SYCP1 protein
	C1ORF146 interacts with synaptonemal complex protein 1 (SYCP1) and synaptonemal complex central element 3 (SYCE3)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS