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FLASH GENE
Symbol NCAPD3 contributors: mct - updated : 25-06-2019
HGNC name non-SMC condensin II complex, subunit D3
HGNC id 28952
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • may playing an essential role in mitotic chromosome assembly and segregation
    • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • initial phase of chromosome condensation requires CDK1-mediated phosphorylation of the NCAPD3 subunit of condensin II
  • down-regulates transcription of genes that encode amino acid transporters (SLC7A5 and SLC3A2) to promote bacterial autophagy by colon epithelial cells
  • Condensin II subunits, NCAPD3 and NCAPH2, interact with members of the Gamma-Interferon Activated Inhibitor of Translation (GAIT) complex
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCPH22
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a new biomarker for subtype-1 prostate tumors that improves prognostication, and reveal androgen signaling as an important biologic feature of this potentially clinically favorable molecular subtype
    • Therapy target
    ANIMAL & CELL MODELS