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FLASH GENE
Symbol NCAPD3 contributors: mct - updated : 25-06-2019
HGNC name non-SMC condensin II complex, subunit D3
HGNC id 28952
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
 liver   moderately
Endocrineparathyroid   highly
Lymphoid/Immunelymph node   highly
 thymus   lowly
Reproductivemale systemprostate  highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • may playing an essential role in mitotic chromosome assembly and segregation
    • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • initial phase of chromosome condensation requires CDK1-mediated phosphorylation of the NCAPD3 subunit of condensin II
  • down-regulates transcription of genes that encode amino acid transporters (SLC7A5 and SLC3A2) to promote bacterial autophagy by colon epithelial cells
  • Condensin II subunits, NCAPD3 and NCAPH2, interact with members of the Gamma-Interferon Activated Inhibitor of Translation (GAIT) complex
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCPH22
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a new biomarker for subtype-1 prostate tumors that improves prognostication, and reveal androgen signaling as an important biologic feature of this potentially clinically favorable molecular subtype
    • Therapy target
    ANIMAL & CELL MODELS