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FLASH GENE
Symbol NCAPD3 contributors: mct - updated : 25-06-2019
HGNC name non-SMC condensin II complex, subunit D3
HGNC id 28952
DNA
TYPE functioning gene
STRUCTURE 73.01 kb     35 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
35 - 5661 169 1498 - 2003 14532007
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
 liver   moderately
Endocrineparathyroid   highly
Lymphoid/Immunelymph node   highly
 thymus   lowly
Reproductivemale systemprostate  highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • may playing an essential role in mitotic chromosome assembly and segregation
  • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • initial phase of chromosome condensation requires CDK1-mediated phosphorylation of the NCAPD3 subunit of condensin II
  • down-regulates transcription of genes that encode amino acid transporters (SLC7A5 and SLC3A2) to promote bacterial autophagy by colon epithelial cells
  • Condensin II subunits, NCAPD3 and NCAPH2, interact with members of the Gamma-Interferon Activated Inhibitor of Translation (GAIT) complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCPH22
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a new biomarker for subtype-1 prostate tumors that improves prognostication, and reveal androgen signaling as an important biologic feature of this potentially clinically favorable molecular subtype
  • Therapy target
    ANIMAL & CELL MODELS