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FLASH GENE

Symbol

NCAPD3

contributors: mct - updated : 25-06-2019

HGNC name	non-SMC condensin II complex, subunit D3
HGNC id	28952

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	73.01 kb     35 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015261 35 - 5661 NP_056076 169 1498 - 2003 14532007

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   moderately   liver       moderately Endocrine parathyroid       highly Lymphoid/Immune lymph node       highly   thymus       lowly Reproductive male system prostate     highly Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION

may playing an essential role in mitotic chromosome assembly and segregation

CELLULAR PROCESS	cell cycle, division

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	initial phase of chromosome condensation requires CDK1-mediated phosphorylation of the NCAPD3 subunit of condensin II
	down-regulates transcription of genes that encode amino acid transporters (SLC7A5 and SLC3A2) to promote bacterial autophagy by colon epithelial cells
	Condensin II subunits, NCAPD3 and NCAPH2, interact with members of the Gamma-Interferon Activated Inhibitor of Translation (GAIT) complex

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MCPH22

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	is a new biomarker for subtype-1 prostate tumors that improves prognostication, and reveal androgen signaling as an important biologic feature of this potentially clinically favorable molecular subtype
Therapy target

ANIMAL & CELL MODELS