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FLASH GENE

Symbol

LIG4

contributors: mct/npt - updated : 15-04-2015

HGNC name	ligase IV, DNA, ATP-dependent
HGNC id	6601

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

LIG4S

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in the bone marrow of adult myelodysplastic syndromes (Economopoulou 2010) tumoral     --low   by hypermethylation in colorectal cancer

Susceptibility

multiple myeloma to glioma

Variant & Polymorphism SNP	T91CT and T91TT protecting against multiple myeloma
	SNP increasing the risk of glioma

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS