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FLASH GENE
Symbol GPR158 contributors: mct - updated : 09-03-2016
HGNC name G protein-coupled receptor 158
HGNC id 23689
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • having a a functional bipartite NLS
  • lacking the ligand binding VFT domain, but it has conserved amino acids involved in G protein binding
  • several phosphorylation sites in the cytoplasmic tail for protein kinases involved in cell cycle progression
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text
  • both endogenous and GC overexpressed GPR158 show an unusual subcellular localization pattern, being found almost entirely in the nucleus
  • plasma membrane GPR158 acts as an anchor for RGS7 complexes, thus may modulate the signaling of other GPCRs
    • basic FUNCTION
  • having metabotropic glutamate, GABA-B-like receptor activity
  • role for elevation of GPR158 expression in glucocorticoid (GC)-induced ocular hypertension
  • essential role for the nuclear translocation in control of cell proliferation
  • is GC-inducible through transcriptional mechanisms in trabecular meshwork (TBM) cells derived from the eye aqueous outflow pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RGS7 is controlled by interaction with two previously uncharacterized orphan GPCRs: GPR158 and GPR179
  • involvement of CCND1, an important regulator of cell cycle progression from G1 to S phase, in linking nuclear function of GPR158 to cell proliferation
  • GPR158 is an essential regulator of RGS7 in the native nervous system with a critical role in controlling its expression, membrane localization, and catalytic activity
  • GPR158 could bind to the RGS7 homo-oligomer without causing its dissociation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    pharmaceuticals targeting GPR158 activities could represent a novel and innovative approach to the prevention and management of castration-resistant prostate cancer (CRPC)
    ANIMAL & CELL MODELS