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FLASH GENE

Symbol

GPR158

contributors: mct - updated : 09-03-2016

HGNC name	G protein-coupled receptor 158
HGNC id	23689

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	having a a functional bipartite NLS
	lacking the ligand binding VFT domain, but it has conserved amino acids involved in G protein binding
	several phosphorylation sites in the cytoplasmic tail for protein kinases involved in cell cycle progression

HOMOLOGY

Homologene

FAMILY

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nucleus
text	both endogenous and GC overexpressed GPR158 show an unusual subcellular localization pattern, being found almost entirely in the nucleus
	plasma membrane GPR158 acts as an anchor for RGS7 complexes, thus may modulate the signaling of other GPCRs

basic FUNCTION	having metabotropic glutamate, GABA-B-like receptor activity
	role for elevation of GPR158 expression in glucocorticoid (GC)-induced ocular hypertension
	essential role for the nuclear translocation in control of cell proliferation
	is GC-inducible through transcriptional mechanisms in trabecular meshwork (TBM) cells derived from the eye aqueous outflow pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	RGS7 is controlled by interaction with two previously uncharacterized orphan GPCRs: GPR158 and GPR179
	involvement of CCND1, an important regulator of cell cycle progression from G1 to S phase, in linking nuclear function of GPR158 to cell proliferation
	GPR158 is an essential regulator of RGS7 in the native nervous system with a critical role in controlling its expression, membrane localization, and catalytic activity
	GPR158 could bind to the RGS7 homo-oligomer without causing its dissociation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate pharmaceuticals targeting GPR158 activities could represent a novel and innovative approach to the prevention and management of castration-resistant prostate cancer (CRPC)

ANIMAL & CELL MODELS