SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic,granule
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,nucleus,nucleoplasm,nuclear bodies
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| intracellular,nucleus,nucleolus
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| text
| its translocation from the nucleolus to the nucleus found with IMPDH inhibition does not mediate the inhibition of rRNA synthesis  |
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shuttles rapidly between the nucleus and the cytoplasm by virtue of a bidirectional nuclear transport domain (NTD) located in its carboxyl terminus |
| basic FUNCTION
| forming a matrix of keratin intermediate filaments which contribute to the structure of hair fibers |
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involved in transcription and RNA processing |
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plays a role in promoting the DNA processing function of WRN, which in turn might be necessary for maintaining genomic stability |
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involved in multiple cellular processes and the life cycles of many viruses |
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essential for survival of cultured hepatoma cells and the ATPase activity appears to be important for this critical role |
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acting as a bridging factor linking nuclear beta-actin with Pol II |
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substrate for EIF2AK2, with phosphorylation perturbing the association of the helicase with double-stranded RNA (dsRNA) |
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cooperative functions for WRN and DHX9 at both migrating and stalled replication forks, where they seem to be involved in the removal of primer RNA-containing Okazaki fragments |
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role in maintaining genome integrity by unwinding mutagenic triplex DNA structures |
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possesses strand displacement activity on triplex DNA structures containing a 3prime-single-stranded overhang, but undetectable activity on the blunt-end duplex DNA structures |
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having ability to preferentially resolve mutagenic triplex DNA structures in an ATP-dependent fashion |
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DDX3X, DDX1 and DHX9 are among the helicases that are required for the replication of a diverse range of viruses |
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is involved in preventing genomic instability induced by alternatively structured DNA in human cells |
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key participant in a number of gene regulatory steps, including transcriptional, translational, and microRNA-mediated control, DNA replication and maintenance of genomic stabilit |
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its functions include regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability |
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promotes R-loop formation in cells with impaired RNA splicing |
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nuclear matrix associated protein that facilitates a number of nuclear functions including initiation of DNA replication, epigenetic maintenance and associates with the inactive X-chromosome |
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DHX9 plays an integral role in repairing DNA breaks through homologous recombination (HR) via its recruitment of BRCA1 to DSBs |
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critical role for DHX9, a RNA helicase involved in the processing of pre-mRNA during transcription, in the initiation of HR |
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role for DHX9 in the DNA Damage Response that provides a critical link between RNA, RNA Pol II and the repair of DNA damage by homologous recombination |
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transcriptional regulator, which is consistent with its mostly nucleic localization, and is also involved in recognizing RNA viruses in the cytoplasm |
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is crucial for host resistance to RNA virus infections, and plays an important role in antiviral immunity |
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is a critical regulator of mammalian neurodevelopment and neuronal homeostasis |
