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FLASH GENE
Symbol GGCT contributors: mct/npt - updated : 17/09/2008
HGNC name gamma-glutamyl cyclotransferase
HGNC id 21705
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer dimer
HOMOLOGY
Homologene
FAMILY
  • BtrG-like family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • catalyzes the formation of 5-oxoproline (pyroglutamic acid) from gamma-glutamyl dipeptides and potentially plays a significant role in glutathione homeostasis
  • may play an important role in the induction of apoptosis by GGO in leukemia U937 cells
  • could play a significant role in regulating the synthesis of glutathione by limiting the availability of -glutamylcysteine
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in kidney, mammary gland, and prostate tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target specific inhibitors that may be of value in the treatment of patients with glutathione synthetase deficiency or in manipulating cancer cell proliferation
    ANIMAL & CELL MODELS