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FLASH GENE

Symbol

GGCT

contributors: mct/npt - updated : 17/09/2008

HGNC name	gamma-glutamyl cyclotransferase
HGNC id	21705

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	8.22 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 4 - 1186 21 188 - Oakley (2008)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       moderately   salivary gland       highly Nervous brain       highly Reproductive female system breast mammary gland   moderately Urinary bladder       highly   kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Connective adipose     highly Muscular striatum skeletal   moderately

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic erythrocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

dimer

HOMOLOGY

Homologene

FAMILY

BtrG-like family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

basic FUNCTION	catalyzes the formation of 5-oxoproline (pyroglutamic acid) from gamma-glutamyl dipeptides and potentially plays a significant role in glutathione homeostasis
	may play an important role in the induction of apoptosis by GGO in leukemia U937 cells
	could play a significant role in regulating the synthesis of glutathione by limiting the availability of -glutamylcysteine

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in kidney, mammary gland, and prostate tumors

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	specific inhibitors that may be of value in the treatment of patients with glutathione synthetase deficiency or in manipulating cancer cell proliferation

ANIMAL & CELL MODELS