Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GGCT contributors: mct/npt - updated : 17/09/2008
HGNC name gamma-glutamyl cyclotransferase
HGNC id 21705
Location 7p15-p14      Physical location : 30.536.238 - 30.544.452
Synonym name
  • chromosome 7 open reading frame 24
  • cytochrome c-releasing factor 21
  • hypothetical protein LOC79017
    • Synonym symbol(s) MGC3077, CRF21, C7orf24, FLJ11717, GCTG, Ggc
    DNA
    TYPE functioning gene
    STRUCTURE 8.22 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1186 21 188 - Oakley (2008)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   moderately
     salivary gland   highly
    Nervousbrain   highly
    Reproductivefemale systembreastmammary gland moderately
    Urinarybladder   highly
     kidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectiveadipose  highly
    Muscularstriatumskeletal moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
  • BtrG-like family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • catalyzes the formation of 5-oxoproline (pyroglutamic acid) from gamma-glutamyl dipeptides and potentially plays a significant role in glutathione homeostasis
  • may play an important role in the induction of apoptosis by GGO in leukemia U937 cells
  • could play a significant role in regulating the synthesis of glutathione by limiting the availability of -glutamylcysteine
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in kidney, mammary gland, and prostate tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target specific inhibitors that may be of value in the treatment of patients with glutathione synthetase deficiency or in manipulating cancer cell proliferation
    ANIMAL & CELL MODELS