basic FUNCTION
| CHCHD2, a previously uncharacterized small mitochondrial protein with no known homology to the BCL2 family, is one of the negative regulators of mitochondria-mediated apoptosis |
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its expression seems to correlate with neuroectodermal differentiation potential of pluripotent stem cells |
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functions in two subcellular compartments, displaying a different function in each |
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in the mitochondria it is a stress regulator of respiration that binds to cytochrome c oxidase (COX) whereas in the nucleus it is a transactivator of COX4I2 and other hypoxia-stimulated genes |
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has the unusual property of functioning in both the mitochondria and the nucleus and of having a different function in each |
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is a biorganellar regulator of mitochondria |