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FLASH GENE
Symbol LYRM4 contributors: mct/npt/pgu - updated : 09-05-2014
HGNC name LYR motif containing 4
HGNC id 21365
ASSOCIATED DISORDERS
corresponding disease(s) COXPD19
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
in FRDA patient cells
constitutional       loss of function
disrupts normal mitochondrial and cytosolic iron homeostasis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • Lyrm4 was down-regulated in the prefrontal cortex of mice with microdeletions in the locus syntenic to 22q11.2 patients affected by schizophrenia