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FLASH GENE
Symbol MLIP contributors: mct - updated : 08-02-2012
HGNC name muscular LMNA-interacting protein
HGNC id 21355
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a lamin-binding domain, spaning across exons 1 and 2
  • a highly conserved nuclear localization sequence (PENKKSKQ from AA 721 to 728)
  • CCAAT/enhancer binding protein zeta
    • secondary structure
  • 46p100 of the sequence is beta-strand and 27p100 alpha-helices
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    intracellular,nuclear envelope,lumen
    text
  • co-localizes with lamin A and C in the nuclear envelope, and also co-localizes with promyelocytic leukemia (PML) bodies within the nucleus
  • majority of MLIP is localized to the nuclear envelope and within the nucleus itself
    • basic FUNCTION
  • may serve important biological roles in regulating lamin function that includes important roles in maintaining nuclear structure, chromatin organization, DNA replication, cell cycle regulation, and apoptosis
  • likely to contribute to the mesenchymal phenotypes of laminopathies
  • may represent an innovation of amniotes, an amniote acquisition that may play an important regulatory or functional role that is unique to amniotes
  • may function as a tethering protein linking LMNA to unidentified factors either within the nuclear envelope or within PML bodies
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts directly and co-localizes with lamin A and C in the nuclear envelope
  • interaction with LMNA, and MLIP interaction domain is between AAs 1 and 130 of LMNA, which includes the N-terminal globular head domain plus coil 1A, linker 1, and the first 43 AAs of coil 1B
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS