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FLASH GENE

Symbol

MRAP2

contributors: mct/npt - updated : 07-07-2020

HGNC name	melanocortin 2 receptor accessory protein 2
HGNC id	21232

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   lower in adrenocortical carcinomas (ACC) than in other adrenal tissues

Susceptibility

to hyperphagic obesity, hyperglycemia and hypertension

Variant & Polymorphism other	loss-of-function MRAP2 variants are pathogenic for monogenic hyperphagic obesity, hyperglycemia and hypertension

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Mrap2 complete knockout (KO) mice have increased body weight without detectable changes to food intake or energy expenditure