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FLASH GENE
Symbol PSMC5 contributors: mct - updated : 22-08-2016
HGNC name proteasome (prosome, macropain) 26S subunit, ATPase, 5
HGNC id 9552
Location 17q23.3      Physical location : 61.904.809 - 61.909.386
Synonym name
  • thyroid hormone receptor interacting protein 1
  • Tat-binding protein homolog 10
  • proteasome 26S ATPase subunit 5
  • suppressor for Gal1
  • 26S proteasome AAA-ATPase subunit RPT6
  • Synonym symbol(s) TRIP1, P45, S8, SUG1, SUG-1, TBP10, p45/SUG, RPT6
    DNA
    TYPE functioning gene
    STRUCTURE 4.62 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1372 - 406 - 1999 9927482
    12 - 1507 - 398 - 1999 9927482
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     salivary gland   highly
    Lymphoid/Immunetonsils   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one AAA family chaperone-like (Adenosine triphosphatases Associated with diverse cellular Activities)
  • C terminus with non-HbYX motif is essential for cellular 26 S proteasome assembly
  • HOMOLOGY
    interspecies homolog to yeast Sug1p
    Homologene
    FAMILY
  • PSM,proteasome
  • AAA family
  • CATEGORY chaperone/stress , enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • 19/22S regulator of proteasome, ATPase subunit, involved in proteasome dependent degradation of SP1
  • 26s protease involved in the ATP-dependent degradation of ubiquitinated proteins
  • has a unique role in linking the transcription and degradation processes via its ability to interact with NCOA3
  • implicated in recruiting enzyme complexes responsible for initiating mammalian transcription
  • potential role for ubiquitination of NLRC4 that is enabled by its interaction with PSMC5, leading to caspase 8 activation and cell death
  • plays a critical role in transcription of MHC class I, and the MHC class II-like molecules, HLA-DM and HLA-DO
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component 26 S (prosome-macropain) of multicatalytic proteinase complex of proteasome
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • transcription factor SP1
  • MYO18B interacts with the proteasomal subunit PSMC5 and is degraded by the ubiquitin-proteasome pathway
  • plays an important role in regulating ataxin-3 degradation by the proteasome
  • interacting with NCOA3
  • binds to histone acetyltransferases and to acetylated histone H3 and, in the absence of PSMC5, histone H3 acetylation is dramatically decreased at mammalian promoters
  • binds to AAs 91-253 of NLRC4, which is also the region that the LRR domain binds to, potentiating cell death induced by NLRC4 and LRR-domain-deleted NLRC4, and co-expression of PSMC5 and NLRC4 induces CASP8-dependent cell death
  • PLEKHO1 mediates the SMURF1-PSMC5 interaction and delivers the ubiquitylated substrates to the proteasome
  • NR1I3 interacting with PSMC5 (suppressor for Gal1), a subunit of the 26S proteasome
  • NLRC4 interacts with PSMC5 and induces CASP8-mediated cell death
  • cell & other
    REGULATION
    Other proteasome complex functioning at multiple levels to regulate the functional biology of NR1I3 activity
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS