protein
| transcription factor SP1 |
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MYO18B interacts with the proteasomal subunit PSMC5 and is degraded by the ubiquitin-proteasome pathway |
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plays an important role in regulating ataxin-3 degradation by the proteasome |
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interacting with NCOA3 |
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binds to histone acetyltransferases and to acetylated histone H3 and, in the absence of PSMC5, histone H3 acetylation is dramatically decreased at mammalian promoters |
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binds to AAs 91-253 of NLRC4, which is also the region that the LRR domain binds to, potentiating cell death induced by NLRC4 and LRR-domain-deleted NLRC4, and co-expression of PSMC5 and NLRC4 induces CASP8-dependent cell death |
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PLEKHO1 mediates the SMURF1-PSMC5 interaction and delivers the ubiquitylated substrates to the proteasome |
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NR1I3 interacting with PSMC5 (suppressor for Gal1), a subunit of the 26S proteasome |
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NLRC4 interacts with PSMC5 and induces CASP8-mediated cell death |