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FLASH GENE
Symbol PSMC3 contributors: mct/npt - updated : 09-10-2009
HGNC name proteasome (prosome, macropain) 26S subunit, ATPase, 3
HGNC id 9549
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Digestiveesophagus   highly
 liver    
 salivary gland   highly
Nervousbrain    
Reproductivefemale systemuteruscervix highly
 male systemprostate   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain possessing the leucine zipper structure
  • one AAA family chaperone-like (adenosine triphosphatases associated with diverse cellular activities)
    • HOMOLOGY
    Homologene
    FAMILY
  • PSM, proteasome family
  • AAA ATPase family
    • CATEGORY chaperone/stress , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • 19/22S regulator of proteasome, ATPase subunit contributing to the E3 ubiquitin ligase function of the VHL protein
  • involved in the ATP-dependent degradation of ubiquitinated protein
  • involvement in the control of cell proliferationb (Pollice 2004)
  • multifunctional protein, component of the regulatory subunit of the proteasome, involved in different cellular processes (Pollice 2007)
  • involved in protection of the human oncosuppressor CDKN2A from proteasomal degradation (Pollice 2007)
  • adenosine triphosphatase of 19S regulatory particles of the 26S proteasome, and transcriptional coactivator of thyroid hormone receptor (Satoh 2009)
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component 26S (prosome-macropain) of multicatalytic proteinase complex of proteasome
  • complexing with VHL and HIF1A
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • VHL, HIF1A
  • interacts with the human immunodeficiency virus tat transactivator
  • directly bound PSMC3IP through the N-terminal domain possessing the leucine zipper structure (Satoh 2009)
  • directly binds AR and might participate in AR-mediated transcriptional activation in cooperation with PSMC3IP (Satoh 2009)
  • interacting with CDKN2A (Pollice 2004))
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS