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FLASH GENE
Symbol SCFD1 contributors: mlc/npt - updated : 12-12-2007
HGNC name sec1 family domain containing 1
HGNC id 20726
Location 14q12      Physical location : 31.091.520 - 31.205.018
Synonym name
  • chromosome 14 open reading frame 163
  • vesicle transport-related protein
  • syntaxin-binding protein 1-like 2
  • Synonym symbol(s) RA410, KIAA0917, STXBP1L2, C14orf163, SLY1, RSLY1, Sly1p
    DNA
    TYPE functioning gene
    STRUCTURE 113.50 kb     25 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 2156 - 642 - Matsuo, Beausoleil (2004)
    24 - 2085 - 575 - Matsuo, Beausoleil (2004)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrineneuroendocrinepituitary  highly
    Nervousbrain    
    Reproductivefemale systemuterus  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Ra410
    homolog to murine Scfd1
    Homologene
    FAMILY
  • STXBP/UNC-18/SEC1 family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • may be involved in vesicular transport between the endoplasmic reticulum and the Golgi
  • having a function intimately associated with syntaxin binding, perhaps promoting a later step in SNARE complex formation or function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • STX5
  • interacting with the COG tethering complex via the COG4 subunit, interaction that is required for Golgi SNARE pairing (Laufman 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS