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FLASH GENE
Symbol LRFN5 contributors: mlc/npt - updated : 28-02-2014
HGNC name leucine rich repeat and fibronectin type III domain containing 5
HGNC id 20360
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven leucine-rich repeats domain (LRR)
  • a fibronectin type-III domain (Fn)
  • an immunoglobulin-like domain (Ig-like)
  • lack PDZ binding domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Lrfn5 (96,59 pc)
    homolog to rattus Lrfn5_predicted (96,24 pc)
    Homologene
    FAMILY
  • LRFN family
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • neuronal components with a role in the developing or mature vertebrate nervous system
  • play critical roles in the formation and maintenance of the central nervous system
  • its expression in nonneural and neural cells induces both excitatory and inhibitory presynaptic differentiation in contacting axons
  • with LRFN4, may promote synapse formation through distinct mechanism
  • expression of LRFN4, LRFN5 in nonneural and neural cells induces both excitatory and inhibitory presynaptic differentiation in contacting axons
  • LRFN4, LRFN5 possess synaptogenic activity, inducing presynaptic differentiation in contacting axons
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homomeric or heteromeric complexes in brain and heterologous cells
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AUTS22
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS