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FLASH GENE
Symbol LRFN5 contributors: mlc/npt - updated : 28-02-2014
HGNC name leucine rich repeat and fibronectin type III domain containing 5
HGNC id 20360
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   moderately
 nerve   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective   predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven leucine-rich repeats domain (LRR)
  • a fibronectin type-III domain (Fn)
  • an immunoglobulin-like domain (Ig-like)
  • lack PDZ binding domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Lrfn5 (96,59 pc)
    homolog to rattus Lrfn5_predicted (96,24 pc)
    Homologene
    FAMILY
  • LRFN family
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • neuronal components with a role in the developing or mature vertebrate nervous system
  • play critical roles in the formation and maintenance of the central nervous system
  • its expression in nonneural and neural cells induces both excitatory and inhibitory presynaptic differentiation in contacting axons
  • with LRFN4, may promote synapse formation through distinct mechanism
  • expression of LRFN4, LRFN5 in nonneural and neural cells induces both excitatory and inhibitory presynaptic differentiation in contacting axons
  • LRFN4, LRFN5 possess synaptogenic activity, inducing presynaptic differentiation in contacting axons
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homomeric or heteromeric complexes in brain and heterologous cells
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AUTS22
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS