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FLASH GENE
Symbol NUBPL contributors: mct - updated : 29-04-2013
HGNC name nucleotide binding protein-like
HGNC id 20278
Corresponding disease
MEIO2 mitochondrial encephalopathy, infantile-onset.2
Location 14q12      Physical location : 32.030.590 - 32.330.417
Synonym name
  • chromosome 14 open reading frame 127
  • iron-sulfur protein required for NADH dehydrogenase
  • Synonym symbol(s) FLJ12660, C14orf127, IND1, huInd1
    DNA
    TYPE functioning gene
    STRUCTURE 299.84 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3072 - 319 - 2009 19752196
    9 - 2836 - 223 - 2009 19752196
    6 - 2739 - 136 - 2009 19752196
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     mouth   highly
    Lymphoid/Immunethymus   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Nubpl (84.5pc)
    homolog to rattus Nubpl (88.1pc)
    Homologene
    FAMILY
  • MRP/NBP35 ATP-binding proteins family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • required for biogenesis and export of both ribosomal subunits
  • critically required for the assembly of the respiratory complex I (NADH:ubiquinone oxidorecutase), with a possible role in the delivery of one or more Fe/S clusters to complex I subunits
  • mitochondrial P-loop NTPase
  • assembly factor for complex I
  • essential for the incorporation of Fe/S clusters into complex I subunits
  • involved in assembly of iron-sulfur clusters early in the complex I assembly pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • ATP binding
  • can bind an Fe/S cluster via a conserved CXXC motif in a labile fashion (Sheftel 2009)
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MEIO2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS