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FLASH GENE
Symbol GPI contributors: mct - updated : 30-12-2015
HGNC name glucose-6-phosphate isomerase
HGNC id 4458
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY
  • GPI family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • neurotrophic factor for spinal and sensory neurons
  • involved in glycolysis, gluconeogenesis, energy pathways
  • role in the differentiation and survival of neural stem cells (NSCs)
  • plays a pathophysiologic role in rheumatoid arthritis by stimulating the proliferation, inhibiting the apoptosis, and increasing pro-inflammatory cytokine secretion of fibroblast-like synoviocytes (FLS)
  • AMFR is the cell surface receptor for autocrine motility factor (GPI), which prevents AMFR-dependent mitofusin degradation
  • multifunctional protein that stimulates cell growth and migration, together with its receptor autocrine motility factor receptor (AMFR)
  • promotes cell proliferation and secretion of type II collagen, a marker of proliferating chondrocytes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL6 and Th17 play an essential role in GPI-induced arthritis
  • polyubiquitylation of GPI requires cooperative interaction between AMFR and the ubiquitin ligase TRIM25
  • OXR1 modulates the additional and less well-understood roles of GPI as a cytokine and neuroprotective factor
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GPID
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate factor that can be applied in the treatment of cartilage defects
    • Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmunearticular
    B cell depletion reduces the number of autoreactive T helper cells and prevents GPI-induced arthritis
    ANIMAL & CELL MODELS