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FLASH GENE
Symbol GPI contributors: mct - updated : 30-12-2015
HGNC name glucose-6-phosphate isomerase
HGNC id 4458
Corresponding disease
GPID glucose phosphate isomerase deficiency
Location 19q13.11      Physical location : 34.855.644 - 34.893.321
Synonym name
  • glucose phosphate isomerase
  • autocrine motility factor
  • neuroleukin
  • sperm antigen 36
  • oxoisomerase
  • hexose monophosphate isomerase
  • phosphohexomutase
    • Synonym symbol(s) NLK, AMF, PGI, PHI, GNPI, SA36, DKFZp686C13233
    EC.number 5.3.1.9
    DNA
    TYPE functioning gene
    STRUCTURE 42.82 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 4275 - 569 - 1995 8530082
    18 - 4212 - 558 - 1995 8530082
    19 - 4356 - 597 - 1995 8530082
    17 - 4125 - 530 - 1995 8530082
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
     thyroid    
    Nervousbrain    
    Reproductivefemale systembreastmammary gland  
     male systemprostate   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • GPI family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • neurotrophic factor for spinal and sensory neurons
  • involved in glycolysis, gluconeogenesis, energy pathways
  • role in the differentiation and survival of neural stem cells (NSCs)
  • plays a pathophysiologic role in rheumatoid arthritis by stimulating the proliferation, inhibiting the apoptosis, and increasing pro-inflammatory cytokine secretion of fibroblast-like synoviocytes (FLS)
  • AMFR is the cell surface receptor for autocrine motility factor (GPI), which prevents AMFR-dependent mitofusin degradation
  • multifunctional protein that stimulates cell growth and migration, together with its receptor autocrine motility factor receptor (AMFR)
  • promotes cell proliferation and secretion of type II collagen, a marker of proliferating chondrocytes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL6 and Th17 play an essential role in GPI-induced arthritis
  • polyubiquitylation of GPI requires cooperative interaction between AMFR and the ubiquitin ligase TRIM25
  • OXR1 modulates the additional and less well-understood roles of GPI as a cytokine and neuroprotective factor
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GPID
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate factor that can be applied in the treatment of cartilage defects
    • Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmunearticular
    B cell depletion reduces the number of autoreactive T helper cells and prevents GPI-induced arthritis
    ANIMAL & CELL MODELS